Defective sarcoplasmic reticulum–mitochondria calcium exchange in aged mouse myocardium
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چکیده
منابع مشابه
Relation between reverse sodium-calcium exchange and sarcoplasmic reticulum calcium release in guinea pig ventricular cells.
Exchange-inhibitory peptide (XIP) can inhibit sodium-calcium exchange without inhibiting L-type calcium current (ICa). We therefore used this compound to test the hypothesis that reverse sodium-calcium exchange can trigger contraction in guinea pig ventricular myocytes. When cells were dialyzed with 20 mmol/L sodium, rapid blockade of ICa with nifedipine had little effect on cell shortening. Ho...
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This study examined the possibility that the postischemic mechanical depression observed in the "stunned" myocardium is a result of an alteration in the control of intracellular calcium. Regional myocardial stunning was produced in five open-chest dogs by eight to twelve 5-minute occlusions of the left anterior descending coronary artery, alternated with 10-minute reflow periods and followed by...
متن کاملDecreased sarcoplasmic reticulum calcium content is responsible for defective excitation-contraction coupling in canine heart failure.
BACKGROUND Altered excitation-contraction (E-C) coupling in canine pacing-induced heart failure involves decreased sarcoplasmic reticulum (SR) Ca uptake and enhanced Na/Ca exchange, which could be expected to decrease SR Ca content (Ca(SR)) and may explain the reduced intracellular Ca (Ca(i)) transient. Studies in other failure models have suggested that the intrinsic coupling between L-type Ca...
متن کاملIlluminating sarcoplasmic reticulum calcium.
The bulk of the Ca 2 that activates contraction in the heart comes from the sarcoplasmic reticulum (SR). Calcium is released by the process of Ca -induced Ca release (CICR) in which the entry of a small amount of Ca across the cell membrane triggers the release of much more from the SR. This mechanism depends on the fact that Ca entry from the extracellular fluid (via the L-type Ca current) inc...
متن کاملSarcoplasmic Reticulum Calcium Uptake
To investigate the mechanism underlying postischemic cardiac dysfunction (myocardial stunning), contractility and adenine nucleotide metabolism were studied in three groups of isolated perfused rabbit hearts (control, ischemic, and reperfused), whereas Ca2` uptake by the sarcoplasmic reticulum (SR) was measured in homogenates obtained from them. The hearts were Langendorff-perfused under consta...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2014
ISSN: 2041-4889
DOI: 10.1038/cddis.2014.526